2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-49066
    Sodium Channel inhibitor 4 587843-16-1 98.0%
    Sodium Channel inhibitor 4 is a sodium channel inhibitor.
    Sodium Channel inhibitor 4
  • HY-49373
    AChE-IN-64 148305-62-8 98%
    AChE-IN-64 (compound C4) is an AChE inhibitor (IC50: 36.9 µM), and can be used for cognitive disorders research.
    AChE-IN-64
  • HY-49463
    Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz
    Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz is an ADC linker that can be used in the synthesis of ADCs (such as Trastuzumab deruxtecan and U3-1402).
    Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz
  • HY-50884
    BMS 433796 935525-13-6 98%
    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
    BMS 433796
  • HY-50892
    (Rac)-Roscovitine 186692-44-4 98%
    (Rac)-Roscovitine ((Rac)-Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac)-Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac)-Roscovitine induces apoptosis in cancer cells. (Rac)-Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation.
    (Rac)-Roscovitine
  • HY-59201
    A-582941 848591-89-9 98%
    A-582941 is a selective, orally active, blood-brain barrier-permeable α7 nAChR agonist, with Ki values of 10.8 nM and 17 nM in rat brain and human frontal cortex, respectively. A-582941 exhibits agonistic activity at 5-HT3 receptors, with a Ki of 150 nM. A-582941 triggers phosphorylation of ERK1/2 and CREB, inhibits GSK-3β via Ser-9 phosphorylation, increases acetylcholine release, induces the expression of Arc and c-Fos, activates brain regions associated with working memory and attention, and reduces cell death caused by nerve growth factor (NGF) deprivation. A-582941 is applicable for the research of Alzheimer's disease and schizophrenia.
    A-582941
  • HY-60252
    (±)-Homoproline 56879-46-0 98%
    (±)-Homoproline (2-Pyrrolidineacetic acid) is the precursor for the biosynthesis of Tussilagine (HY-N1388) and Isotussilagine. (±)-Homoproline can be used in neurological research.
    (±)-Homoproline
  • HY-69172
    RS-25344 152814-89-6 98%
    RS-25344 is a selective inhibitor of phosphodiesterase type IV (PDE4). RS-25344 increases intracellular cAMP (cyclic adenosine phosphate) concentration by inhibiting PDE4 activity. RS-25344 can be used in the study of inflammation, immune diseases, neurodegenerative diseases and cardiovascular diseases.
    RS-25344
  • HY-A0039
    Eletriptan 143322-58-1 98%
    Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine.
    Eletriptan
  • HY-A0137
    Pipotiazine 39860-99-6 98%
    Pipotiazine (Pipotiazine) is a Phenothiazine (HY-Y0055) derivative with neuroleptic activity. Pipotiazine (Pipotiazine) can be used for neurological disease research.
    Pipotiazine
  • HY-A0140
    Drotaverine 14009-24-6 98%
    Drotaverine is a selective phosphodiesterase 4 inhibitor with angina relief activity. Drotaverine is used to suppress angina, including pain in the gastrointestinal tract and biliary tract. Drotaverine may also cause compound-induced priapism, a side effect of sustained penile erection.
    Drotaverine
  • HY-A0149
    Phenindamine 82-88-2 98%
    Phenindamine (Nu 1504) is an antihistamine.
    Phenindamine
  • HY-A0157
    Dimethothiazine 7456-24-8 98%
    Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity.
    Dimethothiazine
  • HY-A0171
    Benzoctamine 17243-39-9 98%
    Benzoctamine is an orally active and potent psychoactive agent which possesses tranquillizing properties. Benzoctamine increases the turnover rate of catecholamines. Benzoctamine enhances the [3H]noradrenaline uptake in the rat heart. Benzoctamine also accelerated the disappearance of intracisternally injected [3H]noradrenaline.
    Benzoctamine
  • HY-A0172
    Captodiame 486-17-9 98%
    Captodiame (Captodiamine) is a 5-HT2c receptor antagonist and sigma-1 and D3 dopamine receptor agonist. Captodiame shows antidepressant effect.
    Captodiame
  • HY-A0175
    Butriptyline 35941-65-2 98%
    Butriptyline (Butriptylene) is an orally active tricyclic antidepressant that slightly enhances central 5-HT effects. Butriptyline does not inhibit brain norepinephrine uptake. Butriptyline can be used for depression research.
    Butriptyline
  • HY-A0179
    Paramethasone 53-33-8 98%
    Paramethasone is an orally active long-acting glucocorticoid. Paramethasone directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone can be used in research related to osteoarthritis and endocrinology.
    Paramethasone
  • HY-A0188
    Norzine dimalate 52239-63-1 98%
    Norzine dimalate (Thiethylperazine dimalate), a Phenothiazine (HY-Y0055) derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Norzine dimalate is also a selective ABCC1activator that reduces amyloid-β load in mice. Norzine dimalate has anti-emetic, antipsychotic and antimicrobial effects.
    Norzine dimalate
  • HY-A0202
    NSC-224070 59886-54-3 98%
    NSC-224070 is a diaziridinyl benzoquinone alkylating agent. NSC-224070 can be used for research on central nervous system tumors.
    NSC-224070
  • HY-A0215
    Doxacurium chloride 106819-53-8 98%
    Doxacurium chloride (BW A938U) is a potent non-depolarizing neuromuscular blocking agent. Doxacurium chloride binds to cholinergic receptors to antagonize acetylcholine, resulting in a block of neuromuscular transmission. Doxacurium chloride can be used for the research of neurological diseases.
    Doxacurium chloride
Cat. No. Product Name / Synonyms Application Reactivity